Are ‘Designer Offspring’ Our Destiny?

The promise of gene editing and designer offspring may prove irresistible

Posted by Keith Tidman

It’s an axiom that parents aspire to the best for their children — from good health to the best of admired traits. Yet our primary recourse is to roll the dice in picking a spouse or partner, hoping that the resulting blend of chromosomes will lead to offspring who are healthy, smart, happy, attractive, fit, and a lot else. Gene editing, now concentrated on medical applications, will offer ways to significantly raise the probability of human offspring manifesting the traits parents seek: ‘designer offspring’. What, then, are the philosophical and sociological implications of using gene editing to influence the health-related wellbeing of offspring, as well as to intervene into the complex traits that define those offspring under the broader rubric of human enhancement and what we can and ought to do?

‘All the interests of my reason, speculative as well as practical, combine in the three following questions: What can I know? What ought I to do? What may I hope?’

— Immanuel Kant

The idea is to alter genes for particular outcomes, guided by previous mapping of every gene in the human body. To date, these selected outcomes have targeted averting or curing disorders, like cystic fibrosis, Huntington’s, and sickle-cell disease, stemming from gene mutations. As such, one of the central bioethical issues is for parents to freely decide which disorders are ‘unacceptable’ and thus to prevent or fix through gene editing. The public, and the medical field, already make similar medical decisions all the time in the course of treatments: stem cells to grow transplantable organs, AI-controlled robotic surgery, and vaccinations, among innumerable others. The aim is to avoid or cure health disorders, or minimally to mitigate symptoms.

As a matter of societal norms, these decisions reflect people’s basic notions about the purpose of health science. Yet, if informed parents knowingly choose to give birth to, say, an infant with Down syndrome, believing philosophically and sociologically that such children can live happy, productive lives and are a ‘blessing’, then as a matter of ethics, humanitarianism, and sovereign agency they retain that right. A potential wrinkle in the reasoning is that such a child itself has no say in the decision. Which might deny the child her ‘natural right’ not to go through a lifetime with the quality-of-life conditions the disorder hands her. The child is denied freely choosing her own destiny: the absence of consent traditionally associated with medical intervention. As a corollary, the aim is not to deprive society of heterogeneity; sameness is not an ideal. That is not equivalent, however, to contending that a particular disorder must remain a forever variation of the human species.

‘We are going from being able to read our genetic code to the ability to write it. This gives us the … ability to do things never contemplated before’

— Craig Venter, writing in ‘Heraclitean Fire: Sketches from a Life Before Nature’.

Longer term, people won’t be satisfied limited to health-related measures. They will turn increasingly to more-complex traits: cognition (intelligence, memory, comprehension, talent, etc.), body type (eye and hair colour, height, weight, mesomorphism, etc.), athleticism (fast, strong, agile, endurance, etc.), attractiveness, gender, lifespan, and personality. The ‘designer offspring’, that is, mentioned above. Nontrivially, some changes may be inheritable, passed from one generation to the next. This will add to the burden of getting each intervention right, in a science that’s briskly evolving. Thus, gene editing will not only give parents offspring that conform to their ideals; also, it may alter the foundational features of our very species. These transhumanist choices will give rise to philosophical and sociological issues with which society will grapple. Claims that society is skating close to eugenics —a practice rightly discredited as immoral — as well as specious charges of ‘playing God’ and assertions of dominion may lead to select public backlash, but not incurably so to human-enhancing programs.

Debates will confront thorny issues: risk–reward balance in using gene editing to design offspring; comparative value among alternative human traits; potential inequality in access to procedures, exacerbating classism; tipping point between experimentation and informed implementation; which embryos to carry to term and childhood; cultural norms and values that emerge from designer offspring; individual versus societal rights; society’s intent in adopting what one might call genetic engineering, and the basis of family choice; acceleration and possible redirection of the otherwise-natural evolution of the human species; consequences of genetic changes for humanity’s future; the need for ongoing programmes to monitor children born as a result of gene editing; and possible irreversibility of some adverse effects. It won't be easy.

‘It is an important point to realize that the genetic programming of our lives is not fully deterministic. It is statistical … not deterministic’ 

— Richard Dawkins

The promise of gene editing and designer offspring (and by extension, human enhancement writ large) may prove irresistible and irreversible — our destiny. To light the way, nations and supranational institutions should arrange ongoing collaboration among philosophers, scientists, the humanities, medical professionals, theologians, policymakers, and the public. Self-regulation is not enough. Oversight is key, where malleable guidelines take account of improved knowledge and procedures. What society accepts (or rejects) today in human gene editing and human enhancements may well change dramatically from decade to decade. Importantly, introducing gene editing into selecting the complex traits of offspring must be informed and unrushed. Overarching moral imperatives must be clear. Yet, as parents have always felt a compelling urge and responsibility to advantage their children in any manner possible, eventually they may muse whether genetic enhancements are a ‘moral obligation’, not just a ‘moral right’.